关键词: 妇糜康阴道栓, 血液学, 血液生化学, 家兔

Abstract: Objective To observe the effect of long term administration of Fumikang vaginal suppository on hematology and blood biochemical indexes in rabbits，to provide the scientific basis for its clinical safe use．Method Rabbits were vaginal administrated Fumikang vaginal suppository at dose of 8.586， 2.856，0.952 g/kg respectively，once a day for 6 months．By the end of the test and 4 weeks after drug withdrawal，the hematology and blood biochemical examination were tested．Result Compared with excipient control group，the hemoglobin and hematocrit in 8.586 g/kg dose group were significantly increased(P0.05).In each group，the blood biochemical parameters for those administration for 6 months and 4 weeks after stopping medication and excipient control groups showed no significant difference. Conclusion There was no long-term toxicity on the hematologic and blood biochemical indicators in 2.856 g/kg of Fumikang vaginal suppository.The safe dose of Fumikang vaginal suppository given to rabbit is over 2.865 g/kg, it is equivalently 20 times of clinical dosage(according to 60 kg body weight of adult).

Key words: Fumikang vaginal suppository, hematologic, blood biochemical, rabbit