关键词: 啮齿类实验动物, 病理学诊断, 病理损伤

Abstract: Abstract: Objective In May 2017, National Animal Spongiform Encephalopathy Laboratory has taken samples from 16 units to investigate the health status of Beijing laboratory rodents．Method They collected the heart, liver, spleen, lung, kidney, large intestine and small intestine, and put these organs into 10% Calcium formaldehyde solution for fixation, and then evaluated the rodent experimental animal health by HE staining, oil red O staining and PAS staining method . Result The most of the laboratory rodents remained in good health condition and no obvious pathological damage, but there are also individual animals appear mild lesions mainly include fatty degeneration and focal necrosis of liver, stale hemorrhage of spleen, hyper eosinophilia and mild lung lesions. Conclusion The vast majority of laboratory rodents were pathologically diagnosed as healthy animals. A few animals showed histopathological changes may be associated with feedstuff, feeding environment and transportation stress, and may be improved by strengthening the feeding management.

Key words: laboratory rodents, pathological diagnosis, pathological damage