关键词: <, p>, 生育三烯酚, 奥沙利铂, 结肠癌<, /p>

Abstract: Abstract: Objective To observe the effect of tocotrienol plus Oxaliplatin on mice with colits-associated cancer． Method Male ICＲ mice ( 5weeks old) were randomly divided into 5 groups( n = 20 /group and 10 mice per cage) ，respectively control group，AOM /DSS group，AOM /DSS + OXA group ( 3 mg / kg·bw OXA) ，AOM /DSS + T3 group ( 100 mg / kg·bw T3) and AOM /DSS + OXA + T3 group ( 3 mg / kg·bw OXA and 100 mg / kg·bw T3) ，all animals were sacrificed at the end of the study ( week 20) ． During the course of the experiment，mice were monitored by continuous body weight measurement; At sacrifice，recorded the mice weight and the weight of spleen，colon，calculated the index of spleen and colon，observed the pathological changes of spleen and colon in mice，evaluated the production of inflammation cytokines and chemokines ( TNF，IL-6，IL-4，IL-2) in blood of mice． Ｒesult Compared with control group，the index of spleen and colon was significantly increased in AOM / DSS group，P ＜ 0. 05; Compared with AOM /DSS group，AOM /DSS + OXA and AOM /DSS + OXA + T3 could markedly decline the index of spleen，and the index of colon was decreased in AOM /DSS + OXA + T3 group，P ＜ 0. 05． AOM /DSS + OXA，AOM /DSS + T3 and AOM /DSS + OXA + T3 could inhibit the expression of TNF，and the expression of IL-6 was remarkably decreased in AOM /DSS + OXA，AOM /DSS + OXA + T3 groups; Compared with Control group，AOM /DSS could decline the production of IL-4． Conclusion Tocotrienol and Oxaliplatin were able to improve immunity function，inhibited the development of colorectal cancer．

Key words: <p>tocotrienol, Oxaliplatin, colon cancer</p>