关键词: 联苯双酯, 齐墩果酸, 黄疸型, 保肝

Abstract: Abstract:Objective To observe the protective effects of Bifendate and Oleanolic acid on acute hepatic injury induced by ANIT in olive oil in mice． Method At first，Bifendate and Oleanolic acid were taken by mice and rats． And then 100 mg /kg and 80 mg /kg ANIT were injected into abdominal cavity of mice and rats to damage their liver，respectively． After 48 hours，their fasting serum levels of ALT，AST，TBIL，DBIL，GGT，ALP were measured． The animals were sacrificed and dissected，and the wet weight of their liver and spleen as well were measured． Finally the viscera index was calculated． Result Oleanolic acid significantly reduced the serum ALT， AST and TB in mice，but Bifendate had no liver protection capacity． Bifendate significantly reduced the serum ALT，AST and ALP in rat，but Oleanolic acid had no liver protection effect． Conclusion Oleanolic acid has liver protection effect on liver injury induced by ANIT in olive oil in mice，and Bifendate has liver protection effect on liver injury induced by ANIT in olive oil in rat．

Key words: Bifendate, Oleanolic acid, jaundice type, hepatoprotective effect