关键词: 阿尔兹海默病, 丹参, 三氯化铝, 乙酰胆碱酯酶

Abstract: Abstract: Objective To evaluate the effects of Salvia miltiorrhiza on the ability of learning and memory and acetyl cholinesterase ( AchE) level in brain tissue and serum of aluminium chloride( AlCl3 ) caused AD mouse model． Method The AD mouse model was prepared by intragastric administration of 400 mg /kg AlCl3 for 60 days． Model group ( To fill the stomach and AlCl3 equal dose of normal saline． ) Salvia miltiorrhiza treatment group ( lavage AlCl3 + Salvia miltiorrhiza 1 mL． ) Salvia miltiorrhiza group( lavage salvia miltiorrhiza 1 mL) ． 24 h After the Morris water maze training，learning and memory function of the mice were tested and the levels of acetyl cholinesterase were measured． Result Salvia miltiorrhiza treatment group and Salvia miltiorrhiza group compared with normal control group，the escape latency in mice and the acetyl cholinesterase levels in the brain tissue and serum no obvious change，there was no statistically significant difference ( P ＞ 0. 05) ． The escape latent period in model group，compared with salvia miltiorrhiza treatment group，was prolonged significantly ( P ＜ 0. 05) ． The acetyl cholinesterase levels of AD mouse model in brain tissue and serum were higher than other groups( P ＜ 0. 05) ． Conclusion Salvia miltiorrhiza can improve the learning and memorizing ability of AlCl3 caused AD model mice and lower the acetyl cholinesterase levels in brain tissue and serum，which are the potential mechanisms of its prevention and treatment effects of alzheimer＇s disease．

Key words: alzheimer’s disease, Salvia miltiorrhiza, aluminium trichloride, acetyl cholinesterase