关键词: 急性高甘油三酯血症, 胆固醇, 大鼠模型

Abstract: Abstract:Objective Comparing with the common hyperlipidemia rat model，which was induced by exogenous high-fat feed，explored the blood lipid level and dynamic change trend of acute high blood triglycerides rat model， which was lavage by fructose． Method 48 SD rats were randomly divided into normal diet control group (C1，C2， C3)，high fat diet group (M1)，high fat chyle agent group (M2)，fructose group (M3A，M3B，M4) ． Blood was sampled from rat eyeball angular vein when M1 group was raised by 4 week，M2 group was lavage for 2 w，M3 group was at 0. 5 h after the last lavage，which M3A and M3B groups were established by different fructose doses and times of lavage． M4 group was before lavage，at the time of 8 h ，16 h，24 h，36 h after the last lavage respectively，Serum total cholesterol ( TC)，triglyceride ( TG)，high-density lipoprotein cholesterol (HDL-C)，low density lipoprotein cholesterol ( LDL-C) were tested． Ｒesult In high-fat diet and high fat chyle groups，TC increased significantly ( P ＜ 0. 05 ) but TG was no significant difference． In fructose group ，TG increased significantly( P ＜ 0. 05 ) whereas TC，HDL-C was no obviously difference，furthermore，the blood lipids level between M3A and M3B groups were no difference;In M4 group，TC，HLD -C level decreased as time went on，TG peaked at 8 h，decreased to base value at 36 h． Conclusion TG rapidly rised stability by fructose lavage ， meanwhile，in fructose groups，TG increased obviously，it could achieve the same effect by different doses and times， TG lasts for 36 h．

Key words: acute high blood triglycerides, TC, rat modes