Abstract: Four inbred strains of mice and four inbred strains of rats had been introduced from Beijing since 1989, and maintained in our center. All of these strains, as foundation colonies, were kept according to a modified parallel line system with full brother-sister mating, accompanied with complete pedigree records including breeding record cards, pedigree charts and pedigree books. Up to now, all strains survived to 9~13 generations. We did not find genetic "pollution", with the genetic testing method established by us.other data obtained were normal. The results showed that the method of maintenance is right.

Key words: Inbred strain Mouse Rat Maintenance

摘要： 本单位从1989年陆续引进了8个国际通用的标准近交系大、小鼠，通过5年多的繁殖和保种实践，我们根据每个品系的特点，逐渐摸索出一套科学的保种方法，设计了保种体系，保证了近交系大、小鼠的遗传质量。

关键词: 近交系, 大鼠, 小鼠, 保种