Abstract: Objective To explore the influences of ZhenTian capsule on blood cell composition, liver function, and kidney function. Methods The rats were orally given ZhenTian capsule for 180 days with the doses of 1.315,2.63 and 5.26g(crude medicinal materials)/kg(13,26.1 and 52.2 times of clinic does) while the control group was given the distilled water of the same volume and for 4 weeks of stopping administration. Meanwhile, rats' behavior and appearance were observed, and night shit and urine everyday amounts were measured. The rat's indexes of hematology and biochemistry were determined. Results All the detected indexes were in normal rang. The value of blood routine and biochemical indices in the tested group had no difference compared with controlled group. Conclusion Taking long-time ZhenTian capsule has no a bad influence on blood composition,liver and kidney functions.

Key words: ZhenTian capsule, Long-term toxicity, Index of hematology

摘要： 目的观察珍田胶囊长期服用对机体血细胞成分、肝肾功能的影响。方法珍田胶囊以1.315,2.63,5.26g(生药)/kg(分别相当于人临床剂量的13、26.1、52.2倍),对照组给予相同体积蒸馏水;连续给大鼠灌胃180d,逐日观察动物行为、外观及大小便。停药后继续观察4周,测量大鼠血常规和血生化指标。结果各给药组大鼠一般状况未见明显异常,各种血常规和血液生化指标均与对照组无显著差异。结论珍田胶囊长期服用对机体血液成分及肝肾功能无不良影响。

关键词: 珍田胶囊, 长期毒性, 血液学指标, 血生化