Abstract: The level of biosafety management at university laboratory animal centers is crucial to their high-quality development. Against the backdrop of multidisciplinary integration, establishing a practical and effective biosafety management system has become the foremost priority for all centers. Taking the Model Animal Research Center of Shandong University as a case study, this paper outlines a five-pronged biosafety management system encompassing training protocols, standardized operations, animal quality control, critical process oversight, and emergency response. After over three years of implementation, significant achievements have been realized: training assessment pass rates reached 97.0% with 92.6% participation; 304 quality control documents were established to ensure standardized end-to-end operations; animal infection rates decreased by 95.0% while microbial testing compliance reached 99.8%; material disinfection compliance and air cleanliness reached 96.5% and 98.0%, respectively; emergency response time shortened by 65.1%, with drill participation at 92.7%. This paper explores a multidisciplinary, center-specific biosafety management system that ensures high-quality development while providing a replicable model for domestic university animal centers facing similar management challenges.

Key words: biosafetymanagement, laboratory animal center;multidisciplinary integration;management system;practiceparadigm

摘要： 高校实验动物中心生物安全管理水平是其高质量发展的关键。多学科交叉背景下,构建切合实际、运行有效 的生物安全管理体系,已成为各中心亟待解决的首要问题。本文以山东大学模式动物研究中心为例,构建涵盖培 训体系、标准化管理、动物质量控制、关键流程管控和应急防控五位一体的生物安全管理体系。经过近3年时间运 行,成效显著:培训考核通过率达97.0%,参与率达92.6%;制定304项质控文件,实现全流程规范运行;动物感染 率下降95.0%,微生物检测合格率达99.8%;物料消毒达标率、空气洁净度分别达96.5%、98.0%;应急响应时间缩 短65.1%,演练参与率达92.7%。本文探究多学科交叉背景下契合中心实际的生物安全管理体系,为中心高质量 发展提供保障,也为国内高校实验动物中心破解同类管理难题提供可复制推广的实践范式。

关键词: 生物安全管理, 实验动物中心, 多学科交叉, 管理体系, 实践范式