Abstract: Skin wounds are a significant burden on the healthcare system, and patients who survive severe burn injuries not only suffer significant long-term morbidity and disfigurement, but also develop a range of negative psychological effects that directly impact the combat effectiveness of the military. Xenografts can be used to treat skin wounds, providing new treatments for diseases such as cancer and organ damage. In this article, we summarize the current research status of skin xenografts in the treatment of burns, and focus on the current understanding of the immunological mechanisms of xenograft rejection. And we also summarized the research progress of pigs that have been bred for xenografts in the study of immune rejection to compensate for cross-species molecular incompatibility and protect the grafts from immune damage, in order to further provide guidance for the further development of pig skin for xenografts that is less likely to cause immune rejection in humans. 

Key words: skin, xenografts, progress, prospects 

摘要： 皮肤伤口是医疗保健系统的一个重大负担,严重烧伤存活的患者不仅会遭受严重的长期发病率和毁容,还会 产生一系列的负面心理影响,直接影响了军队的战斗力。 异种移植物可用于治疗皮肤伤口,为癌症、器官损伤等疾 病提供了新的治疗手段。 本文总结了皮肤异种移植在烧伤治疗中的研究现状,并重点关注了目前对异种移植排斥 反应的免疫学机制的理解,以及在免疫排斥反应研究中,已经培育出的用于异种移植的猪以弥补跨物种分子不相 容性以及保护移植物免受免疫损伤的研究进展,为进一步开发出一种不易引起人体免疫排斥反应的异种移植用猪 皮提供指导意见。 

关键词: 皮肤, 异种移植, 进展, 展望