Laboratory Animal Science ›› 2024, Vol. 41 ›› Issue (6): 11-15.DOI: 10. 3969 / j. issn. 1006-6179. 2024. 06. 003

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Effects of Parental Folate Deficiency on Body Weight in Offspring Rats

  

  1. ( 1. School of Public Health, Tianjin Medical University, Tianjin 300070, China)
    ( 2. Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070,China)
  • Received:2023-09-15 Online:2024-12-28 Published:2025-01-15

亲代叶酸缺乏对子代大鼠体质量变化的影响

  

  1. ( 1. 天津医科大学公共卫生学院,天津 300070)  ( 2. 天津市环境营养与人群健康重点实验室,天津 300070)
  • 通讯作者: 闫 婧( 1983—) ,女,博士,副教授,研究方向为孕婴营养、营养与神经科学,E-mail: yanjing@ tmu. edu. cn。 李振舒( 1992—) ,女,博士,讲师,研究方向为营养与神经科学、营养与疾病,E-mail: lizhenshu@ tmu. edu. cn。
  • 作者简介:任庆涵( 2000—) ,女,博士研究生,研究方向为营养与神经科学,E-mail: renqinghan0223@ tmu. edu. cn。
  • 基金资助:
    天津市教委科研计划项目( 2022KJ203)

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Abstract:

Objective The present study was designed to investigate the effect of parental folate deficiency on the body weight of offspring rats. Method The present study was a reproduction experiment in Sprague-Dawley ( SD) rats, where female and male rats were randomly divided into four groups by feeding interventions: parental folate deficient group ( both female and male rats feed folate level <0. 1 mg / kg) ; maternal folate deficient and paternal folate normal group ( female rats feed folate level <0. 1 mg / kg, male rats feed folate level 2. 0 mg / kg) ; maternal folate normal and paternal folate deficient group ( female rats feed folate level 2. 0 mg / kg, male rats feed folate level <0. 1 mg / kg) ; and the group with normal folic acid in both parental generations (2. 0 mg / kg of folic acid in the feed for both female and male rats) . The offspring were weaned at 4 weeks after birth and fed the same diet as their mothers until 13 weeks. The body weight of parental rats, pregnancy rate and prenatal body weight of maternal rats, food intake and body weight of offspring rats were monitored. During the intervention, the body weight of the parental and the offspring rats were recorded. Result The body weight of both parental rats increased with time, and there was no difference in the body weight of the parental among the four groups. The body weight of the offspring increased with time, and the changes of body mass of the offspring rats before and after weaning were lower in D-D group than in the other 3 groups ( P < 0. 05) . 

Conclusion In this study, we haven’ t found folate deficiency could affect the body weight of the parental, while parental folate deficiency may decrease the body weight of the offspring.

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摘要：

目的 探究亲代叶酸缺乏对子代大鼠体质量变化的影响。 方法 本研究为 Sprague-Dawley( SD) 大鼠生殖实验,采用饲料干预的方法,将雌鼠和雄鼠随机分为 4 组:亲代叶酸均缺乏组( D-D 组,雌鼠和雄鼠饲料中叶酸含量均<0. 1 mg / kg) ;母代叶酸缺乏和父代叶酸正常组(D-N 组,雌鼠饲料中叶酸含量<0. 1 mg / kg,雄鼠饲料中叶酸含量为2. 0 mg / kg) ;母代叶酸正常和父代叶酸缺乏组(N-D 组,雌鼠饲料中叶酸含量为 2. 0 mg / kg,雄鼠饲料中叶酸含量<0. 1 mg / kg) ;亲代叶酸均正常组(N-N 组,雌鼠和雄鼠饲料中叶酸含量均为 2. 0 mg / kg) 。 饲喂饲料至母代大鼠分娩,其子代于出生后 4 周断乳,之后饲喂与其母代一致的饲料至 13 周。 监测亲代大鼠体质量、母代大鼠受孕率及产前体质量、子代大鼠摄食量及体质量变化。 在此期间,监测亲代及断乳前后子代大鼠的体质量变化。 结果 亲代大鼠的体质量均随时间变化而增加,4 组间母代和父代大鼠的体质量变化差异均无统计学意义;子代大鼠体质量均随时间变化 而 增 加, 断 乳 前 和 断 乳 后 子 代 大 鼠 的 体 质 量 变 化 均 表 现 为 D-D 组 低 于 其 他 3 组 ( P < 0. 05 ) 。
结论 未发现叶酸缺乏对亲代大鼠体质量产生影响,但亲代叶酸缺乏可能会降低子代大鼠体质量。

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