Laboratory Animal Science ›› 2023, Vol. 40 ›› Issue (3): 84-87.DOI: 10. 3969 / j. issn. 1006-6179. 2023. 03. 014
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Abstract: Objective To observe the effects of two anesthesia method on the experimental result of myocardial perfusion examination using 18F-Flurpiridaz in miniature pigs ( mini pigs ) . Method 4 normal Bama mini pigs were randomly divided into 2 groups with 2 pigs in each group. Group A was anesthetized by intramuscular injection of Lumianning and midazolam. Group B received Zoletil and midazolam combined muscle anesthesia. The result of myocardial perfusion imaging were compared between two groups. Result False positive myocardial perfusion imaging was found in group A,and as expected in group B. Conclusion Base anesthesia of mini pigs can be achieved by both anesthesia programs. However, it is suggested to avoid or reduce the use of Lumianning for combined anesthesia in cardiovascular related experimental examination.
Key words: Lumianning, Midazolam, Zoletil, miniature pig, anesthesia;18F-Flurpiridaz;PET / CT
摘要: 目的 利用18F-Flurpiridaz 进行小型猪心肌灌注检查过程中,观察 2 种麻醉方法对实验结果的影响。 方法 正常实验用普通级巴马小型猪 4 头,随机分为 2 组,每组 2 头。 A 组采用陆眠宁与咪达唑仑复合肌肉注射麻醉;B组采用舒泰与咪达唑仑复合肌肉麻醉。 比较 2 组心肌灌注显像的结果。 结果 A 组的心肌灌注显像出现了假阳性,B 组实验结果如预期。 结论 2 种麻醉方案均可完成小型猪的保定麻醉。 但在进行心血管相关实验检查中,建议避免或减少使用陆眠宁进行复合麻醉。
关键词: 陆眠宁, 咪达唑仑, 舒泰, 小型猪, 麻醉, 18F-Flurpiridaz, PET / CT
CLC Number:
Q95-3
LIU Tianwen. Effect of Different Anesthesia Methods on PET / CT Examination Results of Miniature Pigs[J]. Laboratory Animal Science, 2023, 40(3): 84-87.
刘天文. 不同麻醉方法对小型猪 PET / CT 检查结果的影响[J]. 实验动物科学, 2023, 40(3): 84-87.
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URL: http://www.sydwkx.com/EN/10. 3969 / j. issn. 1006-6179. 2023. 03. 014
http://www.sydwkx.com/EN/Y2023/V40/I3/84