Abstract: Abstract: In physiology，anatomy，histology，diet structure and nutritional metabolism，the miniature pig has become a hot topic in the study of human disease model． This article reviewed the mechanism of type 2 diabetes and the limit of rodent animal models briefly，focusing on advance of the characteristics of high-fat and high-energy diet and drug induced miniature pig model of type 2 diabetes mellitus，genetic engineering models of miniature pig，and the prospect of the development of miniature pig model of type 2 diabetes in the future．

Key words: <p>Type 2 diabetes mellitus, miniature pig, high-fat high-energy diet, genetic engineering, disease model</p>

摘要： 摘要: 小型猪在生理学、解剖组织学、饮食结构和营养代谢等方面与人高度相似，已成为人类疾病模型研究的关注热点。本文在简要介绍2 型糖尿病发生机制和啮齿类动物模型的局限后，重点阐述了高脂高能量饮食和药物诱导小型猪2 型糖尿病模型的特点，及基因工程小型猪模型的研究进展和存在不足，并对小型猪2 型糖尿病模型的发展进行了展望。

关键词: <, p>, 2 型糖尿病, 小型猪, 高脂高能量饮食, 基因工程, 疾病模型<, /p>