Abstract: Abstract:Objective To explore the effect of electro-acupuncture on learning and memory behavior of five months APP / PS1 transgenic AD mice． Method 16 APP /PS1 transgenic positive male mice were randomly divided into the model group and the electro-acupuncture group，8 in each group． At the same time，there were 8 APP /PS1 transgenic negative male mice as the normal control group． The“baihui”and“yongquan”of electro-acupuncture group were acupunctured using dilatational wave for 15 min ，every other day at a time． By the same method ，the mice of control and model group were bounded by binder for 15 min． The all three groups were treatmented for five weeks． Finally the ability of learning and memory of all mice was tested by Morris water maze． Ｒesult Escape latency between three groups was statistically significant( P ＜ 0. 05 )，escape latency between the model group and the electro-acupuncture group was statistically significant ( P ＜ 0. 05 ) ． Conclusion Electro-acupuncture can improve learning and memory ability of APP /PS1 transgenic AD mice．

Key words: electro-acupuneture, APP /PS1, Morris water maze test, learning and memory behavior

摘要： 摘要:目的探讨电针对5 月龄APP /PS1 转基因阿尔茨海默病(Alzheimer's disease，AD)模型小鼠学习记忆行为学 的影响。方法将16 只APP /PS1 转基因阳性雄鼠随机分为模型组、电针组，每组各8 只，8 只APP /PS1 转基因阴 性雄小鼠为对照组，电针组针刺“百会”、“涌泉”穴位后接电针仪，疏密波，每次针刺持续15 min，隔日1 次，对照组、 模型组以相同方法用鼠袋束缚15 min，隔日1 次，3 组都持续5 周，以Morris 水迷宫检测小鼠学习记忆能力。结果 3 组间的鼠逃避潜伏期的差异均有统计学意义(P ＜ 0. 05)，电针组与模型组小鼠之间的差异有统计学意义( P ＜ 0. 05)。结论电针能提高APP /PS1 转基因AD 模型小鼠的学习记忆能力。

关键词: 电针, APP /PS1, Morris 水迷宫, 学习记忆