Abstract: Abstract: Objective To obtain new pentobarbital sodium solution by replacing general method of preparation，and investigate it's anesthetic effect on rats compared with general pentobarbital sodium and chloral hydrate． Method 120 rats were used in this study，which were randomly separated into 3 groups． Each group rats were respectively treated by general pentobarbital sodium，modified pentobarbital sodium and chloral hydrate with intraperitoneal injection，then observed the general state of rats，the acting time and anesthetic time were recorded，which were analyzed by statistics software． Result There were no significantly difference in acting time and anesthetic time between three groups，the variation of acting time and anesthetic time in modified pentobarbital sodium treated group was less than other two groups，and the successfully anesthetic number at first injection was significantly more than other two groups． Conclusion The study showed that the modified pentobarbital sodium could provide the stable anesthetic effect，which function was better than general pentobarbital sodium and chloral hydrate．

Key words: pentobarbital sodium, chloral hydrate, anesthesia, Wistar rat

摘要： 摘要: 目的通过对现有戊巴比妥钠的配制方法进行改进，获得复合型戊巴比妥钠，比较并分析其与普通戊巴比妥 钠、水合氯醛对大鼠的麻醉效果。方法选用120 只Wistar 大鼠，随机分为3 组，应用普通戊巴比妥钠、复合型戊巴 比妥钠及水合氯醛3 种麻醉剂分别对相应大鼠进行腹腔注射麻醉，观察大鼠状态，记录麻醉起效时间及麻醉时间， 并进行分析。结果3 种麻醉剂对大鼠的麻醉起效时间及麻醉时间均无显著性差异，但复合型戊巴比妥钠组内的 大鼠之间的起效时间及麻醉时间差异小于其他两组的大鼠，具有统计学意义，并且复合型戊巴比妥钠组中的大鼠 首次麻醉成功的例数高于其他两组。结论研究表明复合型戊巴比妥钠对大鼠的麻醉作用稳定，麻醉效果优于普 通戊巴比妥钠和水合氯醛。

关键词: 戊巴比妥钠, 水合氯醛, 麻醉, Wistar 大鼠