Abstract: Objective To evaluate the microbi0109ical quality of clean rat and mouse．Methods According to the national standard GB／T 14926-200 1，we collected samples from producing and breeding group in some related farms with a principle of simple random sampling，and detected the serum antibody level of main virus． Results The number of Sendai virus(SV)and hanta virus(HV)antibody positive were negative in 3 1 rats；and the number of positive mouse hepatitis virus(MHV)antibodies is 25，and Sendai virus(SV)1 0，Ectromelia(Ect) in 280 mice．Conclusion The virus monitoring and quality control for mouse of clean grade should be strengthened．

Key words: laboratory animals, serum antibody, rat, mouse

摘要： 目的评估清洁级大鼠、小鼠的微生物学质量。方法参照国家标准GB／T 14926—2001，依据单纯随机抽样 原则从相关单位生产繁殖群采集样品，检测主要病毒血清抗体水平。结果检测31只大鼠，其中仙台病毒(SV)和 汉坦病毒(HV)抗体阳性率均为0；检测280只小鼠，其中25只小鼠肝炎病毒(MHV)抗体阳性，10只小鼠仙台病 毒(SV)抗体阳性，1只小鼠鼠痘病毒(Ect)抗体阳性。结论清洁级小鼠的病毒监测工作及质量控制需加强。

关键词: 实验动物, 血清抗体, 大鼠, 小鼠