Abstract: Objecfive To observe and compare with the changes of ECG before and after anesthetized in guinea pigs．Methods Observed and recorded ECG of guinea pigs in a sober state 30 minutes，administrated intraperitoneally corresponding doses of anesthetic and recorded the ECG 120 minutes，analyzed all the abnormal ECG in guinea pigs and calculate the abnormal rate．Results The abnormal rates of pentobarbital sodium，chloral hydrate，urethane，chloralose，the chloralose-urethan mixture and ether were 37．5％，25％，25％，1 2．5％，25％and 25％．Conclusion Six kinds of anesthetics all have a certain influence to normal ECG in guinea pigs；it is recommended to choose sober guinea pigs for ECG monitoring．

Key words: Anesthetic, Guinea pigs, Electrocardiogram

摘要： 目的观察和比较六种全麻药对豚鼠心电图的影响。方法观察并记录豚鼠在清醒状态下的心电图30 min 以及给予各种相应剂量的麻醉给药后的心电图120 min，对给药后出现的异常心电图进行分析。并计算异常率。结 果戊巴比妥钠、水合氯醛、乌拉坦、氯醛糖、氯-乌合剂和乙醚对豚鼠正常心电图的影响率分别为37．5％、25％、 25％、12．5％、25％和25％。结论六种全麻药均对豚鼠正常心电图有一定的影响，建议选择清醒状态下的豚鼠进 行心电图监测。

关键词: 全身麻醉药, 豚鼠, 心电图