Abstract: Lasiopodomys brandtii is a small rodent. Its natural ecological environment may fluctuate in the oxygen content in the cave due to seasonal changes. Especially during the rainy season and winter, a hypoxic environment is formed in the cave of Lasiopodomys brandtii. It must adopt certain adaptive strategies to maintain its survival. The adaptive mechanisms of Lasiopodomys brandtii in a hypoxic environment show highly complex physiological and molecular coordination. It enhances anaerobic metabolism, activates innate immune responses through oxygen transport and angiogenesis, and downregulates nerve synaptic transmission functions to reduce the body’s energy consumption to cope with hypoxic environments. The adaptive mechanism to the hypoxic environment not only reflects the ability of Lasiopodomys brandtii to adapt to the hypoxic environment, but also reveals the high degree of coordination formed by its physiological and metabolic systems during evolution. The purpose of this paper is to systematically review the adaptability of Lasiopodomys brandtii to hypoxic environment.

Key words: Lasiopodomys brandtii, hypoxic environment, molecular mechanisms of hypoxic environment adaptation

摘要： 布氏田鼠是一种小型啮齿动物,其自然生态环境可能会因季节变化而出现洞穴内氧气含量的波动,尤其是雨 季和冬季,布氏田鼠洞穴里形成低氧环境,其必须采取一定的适应性策略以维持其生存。布氏田鼠在低氧环境中 的适应机制表现出高度复杂的生理和分子层面的协调性。其通过氧气运输和血管生成,增强无氧代谢,激活先天 免疫反应,下调神经突触传递功能以减少机体耗能从而应对低氧环境。低氧环境适应性机制不仅反映了布氏田鼠 对低氧环境的适应能力,更揭示了其生理和代谢系统在进化过程中形成的高度协调性。本文旨在对布氏田鼠的低 氧环境适应性做系统性综述。

关键词: 布氏田鼠, 低氧环境, 低氧环境适应性分子机制