Abstract: Objective　To study the modeling characteristics of qi deficiency and blood stasis syndrome, providing reference for establishing stable and reliable animal models of qi deficiency and blood stasis syndrome.Methods　A systematic review was conducted on the research of animal models of qi deficiency and blood stasis syndrome. Relevant literature on animal models of qi deficiency and blood stasis syndrome was retrieved and a database was established. CiteSpace software was used to conduct visual analysis of animal models of qi deficiency and blood stasis syndrome. ResultsA total of 246 literatures were included in the study. The main experimental animals for qi deficiency and blood stasis syndrome were rats. The main modeling method is sleep deprivation. The combination of disease and syndrome, mainly cardiovascular and cerebrovascular diseases, is a current research hotspot. The future research trend might be the gut microbiota.Conclusion　By summarizing and analyzing the preparation method and research hotspots of the animal model of qi deficiency and blood stasis syndrome, this paper provides a reference for improving the success rate of the animal model, with the aim of laying a foundation for the study of qi deficiency and blood stasis syndrome and its combination of disease and syndrome.

Key words: Qi deficiency and blood stasis syndrome, animal model, combination of symptoms, rat, CiteSpace visual analysis

摘要： 目的　研究气虚血瘀证动物模型造模特点,为建立稳定可靠的气虚血瘀证动物模型提供参考。方法　对气 虚血瘀证动物模型的研究进行系统综述,检索气虚血瘀证动物模型相关文献并建立数据库,使用CiteSpace软件对 气虚血瘀证动物模型进行可视化分析。结果　研究共纳入246篇文献,气虚血瘀证主要实验动物为大鼠;主要造 模方法为睡眠剥夺法;以心脑血管疾病为主的病证结合是当下研究热点;未来研究趋势可能为肠道菌群。结论　 通过对气虚血瘀证动物模型制备方法及研究热点进行总结分析,为其提高动物模型的成功率提供参考,以期为气 虚血瘀证及其病证结合研究提供基础。

关键词: 气虚血瘀证, 动物模型, 病症结合, 大鼠, CiteSpace可视化分析