Abstract: To investigate the effects of cinnamon cortex on the metabolomics of SD rats using
1H NMR combined with multivariate data analysis, to explore pharmacological mechanism of cinnamon
cortex. Method Twenty SD rats were randomly divided into cinnamon cortex-treated groups(CC) and the
control groups ( TCG) . The rats in the cinnamon cortex-treated groups ( CC ) were intragastric with
cinnamon cortex ( CC) decoction at the dose of 0. 5 g / kg, while the rats in the control groups were
intragastric with the same dose of distilled water once a day for 22 days. The dose of cinnamon cortex was
according to the Chinese Pharmacopoeia ( 5 g / person / day ) . It was determined that urine and fecal
samples were collected on day 0, day 5, 10 and 22 after cinnamon cortex administration. Result
Compared with the blank control group, the contents of 8 metabolites and 7 metabolites were significantly
up-regulated in the NMR map of urine samples of the cinnamon cortex administration group on the 22
day. The levels of cadaverine, carnitine, succinate, citric acid and hippuric acid were up-regulated,
while the levels of dimethylamine, creatinine, phenylalanine and glycine were down-regulated. In the
NMR pattern of fecal samples, the contents of 9 biometabolites were down-regulated and 3 up-regulated,
and the levels of adenine and uracil were significantly decreased, while the levels of lactic acid,
succinate and acetone were increased, with statistical significance between groups (P<0. 01,P<0. 05) .Conclusion Cinnamon cortex may exert its pharmacological effects by regulating aromatic amino acid
metabolism, choline degradation, short-chain fat synthesis and other metabolic pathways.

Key words: Cinnamon cortex, metabonomics, NMR

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