Abstract: Objective To explore the anti-inflammatory effect and mechanism of Shegan Zhike capsule. Method The anti-inflammatory effect of Shegan Zhike capsule was observed by ear swelling test in mice and granuloma test in rats. The mechanism of anti-inflammatory action was speculated by detecting the levels of interleukin 6 ( IL-6) and tumor necrosis factor α ( TNF-α) in the serum of mice with lung injury induced by lipopolysaccharide ( LPS) . Result Compared with the blank control group, the low, medium and high doses of Shegan Zhike capsules could significantly reduce the degree of ear swelling in mice, and the difference was significant ( P<0. 01 and P<0. 05) . Compared with the model control group, the low, medium and high doses of Shegan Zhike capsules could significantly reduce the weight of rat granulomas, and the difference was significant ( P < 0. 01 and P < 0. 05) . Compared with the model control group, the low, medium and high doses of Shegan Zhike Capsules could significantly reduce the levels of serum IL-6 and TNF-α in mice, and the difference was significant ( P<0. 01 and P<0. 05) . Conclusion Shegan Zhike capsule has certain anti-inflammatory effect and inhibiting inflammatory factors.

Key words: Shegan Zhike capsule, anti-inflammatory effect, inflammatory factors

摘要： 目的 探讨射干( Belamcanda chinense)止咳胶囊抗炎作用及相关机制。 方法 采用小鼠耳肿胀实验和大鼠肉芽肿实验,观察射干止咳胶囊的抗炎作用,并通过检测经脂多糖( LPS)诱导的肺损伤小鼠血清中白介素 6( IL-6)及肿瘤坏死因子 α( TNF-α)水平,推测其可能的抗炎作用机制。 结果 与空白对照组比较,射干止咳胶囊低、中、高剂量组均能明显降低小鼠耳肿胀度程度,差异有显著意义( P< 0. 01 ~ 0. 05) ;与模型对照组相比,射干止咳胶囊低、中、高剂量组能够明显降低大鼠肉芽肿的质量,差异有统计学意义( P< 0. 01 ~ 0. 05) ;与模型对照组比较,射干止咳胶囊低、中、高剂量组能够明显降低小鼠血清 IL-6 和 TNF-α 水平,差异有统计学意义( P< 0. 01 ~ 0. 05) 。 结论 射干止咳胶囊具有一定的抗炎作用,其作用机制可能与抑制炎症因子合成及释放有关。

关键词: 射干止咳胶囊, 抗炎作用, 炎症因子