Abstract: Objective To provide reference to production, management and detection of laboratory animals by comparative analyzing of the recently 3 years’ test result from 2017 to 2019 on microbes and genetics of laboratory animals in Beijing area. Method According to the national and local standards, relevant law and regulation, the laboratory animal production units in Beijing area were randomly inspected and the tested. According to the data, 8 species of the laboratory animals including mice, rats, guineas, shrews, rabbits, dogs, monkeys and minipigs were classified according to their breeds, grades, units, etc. , and their quality problems were analyzed. The change in trend analysis of the quality of the laboratory then was analyzed and compared with the same period from 2014 to 2016. Result From 2017 to 2019, there were 144, 131 and 135 batches of random testing annually, while 30, 15 and 17 unqualified batches, respectively. The main reasons for disqualification were the immunity level dissatisfaction (20 batches in rabbits, dogs and minipigs) and 20 batches were infected by pathogens. No genetic variation was found. Compared with the relevant results from 2014 to 2016, no genetic problems have been detected. The status of substandard immunity has improved and pathogenic infections have increased. Conclusion This result can provide support to the healthy development of the laboratory animal industry.

摘要:目的 比对分析 2017—2019 年北京地区实验动物微生物及遗传质量监测结果,为实验动物产业发展提供参考。 方法 按照国家和地方现行实验动物检测标准,对北京地区实验动物生产单位进行抽检,并发布检测报告。按照报告数据,对此阶段小鼠、大鼠、豚鼠、地鼠、兔、犬、猴和小型猪共 8 个品种的实验动物按照品种、等级、单位等进行分类,分析质量问题,并与 2014—2016 年同期实验动物质量比对,分析变化趋势。 结果 2017—2019 年分别抽检动物 144、131 和 135 批次,检出不合格批次分别为 30、15 和 17 批。 不合格主要因素为兔、犬及猪免疫不达标(20 批) ,病原感染 20 批,未发现遗传变异。 与 2014—2016 年同期相比,未检出遗传问题相同,免疫不达标状况好转,但病原感染出现上升。 结论 通过质量分析比对,能够为实验动物产业健康发展提供数据支持。