Abstract:Genetic quality monitoring is one of the most important composition of laboratory animal quality control.It is essential method to find the genetic variation in laboratory animal and to confirm standardized animal quality. With the development of science and technology, especially with biological science progress, the technique of laboratory animal quality monitoring boosts from morphological genetic markers to DNA molecular level, and become more accurate, convenient and speedy. We sort out the history about methods in laboratory animal quality control, compare and analyze the advantages and limits of these methods, discuss the bright prospect of their application as well.

摘要:遗传质量监测是实验动物质量控制的重要内容之一,也是发现实验动物遗传变异及保障动物质量符合要求的重要手段。 随着科学技术发展,尤其是生物科学的不断进步,实验动物遗传质量监测技术也从形态学遗传标记发展到 DNA 分子水平,越来越趋于准确、简便和快速。 本文梳理了实验动物遗传质量监测技术沿革,分析比较了各项技术的优点和局限性,并对其应用前景进行了展望。