Abstract: Abstract: Objective Preform the animal experimental study to research the characteristics of intervertebral disc biomechanical strength in different periods after the annulus fibrosus suture． Method A total of 40 sheep were underwent retroperitoneal 3 levels exposure of the lumbar spine． The Control Group did not penetrate into the annulus fibrosus． The Ｒesearch Group penetrated into the annulus fibrosus and perform annulus fibrosus suture． In Ｒesearch Group，at 3 months after surgery，Group A were taken MＲI images and underwent biomechanical testing to assess the strength of the disc． Histology was also conducted． Group B were performed 6 months after surgery． Group C were performed 12 months after surgery． Ｒesult The biomechanical strength of the disc at 3 months after operation was( 1. 39 ± 0. 68) MPa，( 2. 04 ± 0. 88) MPa at 6 months． ( 3. 58 ± 1. 10) MPa at 12 months，and it was close to the Control Group with( 3. 90 ± 1. 59) MPa． In Ｒesearch Group，loss of intervertebral height was( 1. 01 ± 0. 29) mm after 3 months． ( 1. 90 ± 0. 65) mm after 6 months，( 2. 04 ± 0. 85) mm after 12 months． Conclusion Annulus fibrosus suture play an important role in the maintenance of the mechanical strength of the intervertebral disc，also promote the repair of annulus fibrosus． And the biomechanical strength of the intervertebral disc was correlated with the repair time of annulus fibrosus．

Key words: <p>disc, annulus fibrosus suture, repair process, experimental study</p>

摘要： 摘要: 目的 观察纤维环缝合术后不同时期椎间盘生物力学强度及纤维环修复特征。方法 成年健康山羊 40 只，雌雄各 20 只，随机分为 4 组，进行椎间盘纤维环暴露术。实验组切开纤维环摘除髓核后进行纤维环缝合; 记录髓核摘除量。对照组仅暴露而不切开纤维环及摘除髓核。实验组 A 组于术后 3 个月时行椎间盘核磁共振及组织学检查、测定椎间盘内压力及椎间隙高度。B 组于术后 6 个月测量上述指标。C 组于术后 12 个月测量。结果 术后 3 个月椎间盘生物力学强度为( 1. 39 ± 0. 68) 兆帕。6 个月为( 2. 04 ± 0. 88) 兆帕。12 个月为( 3. 58 ± 1. 10) 兆帕，接近对照组( 3. 90 ± 1. 59) 兆帕。实验组术后 3 个月椎间隙高度丢失为( 1. 01 ± 0. 29) mm，术后 6 个月为( 1. 90 ± 0. 65) mm，术后 12 个月为( 2. 04 ± 0. 85) mm。三者进行组间比较有统计学意义。结论 纤维环缝合术对维持椎间盘生物力学强度及术后纤维环修复起到积极作用。椎间盘生物力学强度恢复与纤维环修复时间相关。

关键词: <, p>, 椎间盘, 纤维环缝合, 修复时间, 实验研究 <, /p>