Abstract: Abstract: Objective To study the protective effct of celecoxib on epileptic rats．Method Kainic acid( KA，1 μg /μL，1. 0 μL) was injected into hippocampus to establish epilepsy model in rats and surveyed the behavioristics changes; immunohistochemical analysis was used to detect the Iba-1 and GFAP of hippocampus． Ｒesult Compared with model group，celecoxib group extended the incubation and reduced the largest seizures rank significantly; decreased the expression of Iba-1 and GFAP，attenuated the hippocampus glial activation caused by KA． Conclusion Celecoxib may inhibit the activity of gia cell to alleviate the gial-mediated inflammation，and lighten the degree of epilepsy．

Key words: <p>celecoxib, epilepsy, Iba-1, GFAP, inflammation</p>

摘要： 摘要: 目的研究选择性COX-2 抑制剂塞来昔布对癫痫大鼠的保护作用。方法采用海马内注射海人藻酸( Kainic Acid，KA，1 μg /μL， 1. 0 μL) 建立大鼠癫痫模型，观察并记录各组大鼠注射KA 后的行为学变化; 采用免疫组化法检测大鼠海马组织中离子钙接头蛋白分子( Iba-1) 和胶质纤维酸性蛋白( GFAP) 的表达情况。结果塞来昔布组的癫痫发作潜伏期明显延长，最大发作级别明显降低( P ＜ 0. 05) ; 与模型组相比，塞来昔布组的海马组织中Iba-1 和GFAP 的表达减少，胶质细胞活化情况明显减轻。结论塞来昔布可能通过抑制小胶质细胞和星形胶质细胞活化，减轻其介导的炎症反应，改善癫痫发作的程度。

关键词: <, p>, 塞来昔布, 癫痫, Iba-1, GFAP, 炎症<, /p>