Abstract: Abstract: To study the effect of HSYA and β-boswellic acid ( BA) on the whole blood viscosity and blood coagulation in blood-stasis model rats． 40 SD rats were randomly divided into control group ( constant volume of normal saline) ，model group ( constant volume of normal saline) ，HSYA group ( 100 mg /kg) ，β-BA group ( 200 mg /kg) ，drug combination group ( HSYA 50 mg /kg + β-BA 100 mg /kg ) ． Ｒats were given relevant medicine intragastrically every 12 h for consecutive 7 times． After the fifth administration， the model rats were given adrenalin hydrochloride ( 0. 7 mg /kg) subcutaneously twice with an interval of 4h． During the interval between two injections， ice-cold water was used to induce acute blood stasis model． Blood samples were collected within 30 min after the last administration to detect the coagulation parameters and the whole blood viscosity at all shear rates．Compared with control group， the whole blood viscosity at all shear rates was increased，and the thrombin time ( TT) ，prothrombin time( PT) and activated partial thromboplastin time( APTT) were all shortened in model group; the content of fibrinogen content( FIB) was increased; there was statistical significance( P ＜ 0. 05) ． Compared with model group，TT and APTT were prolonged and the content of FIB and the whole blood viscosity at all shear rates decreased in HSYA group，β-BA group and drug combination group; there was statistically significant( P ＜ 0. 05) ．The effect of drug combination was more obvious than single drug． HSYA and β-boswellic acid，and significantly improve coagulation function and the whole blood viscosity at all shear rates in blood-stasis model rats．

Key words: <p>blood-stasis, whole blood viscosity, coagulation function</p>

摘要： 摘要: 目的研究羟基红花黄色素A( HSYA) 联用β － 乳香酸( β － BA) 对血瘀证模型大鼠凝血功能和全血粘度的影响。方法将40 只SD 大鼠随机分为空白对照组( 等体积生理盐水) 、模型组( 等体积生理盐水) 、HSYA( 100 mg /kg) 组、β － BA( 200 mg /kg) 组、联合用药( HSYA 50 mg /kg + β － BA 100 mg /kg) 组，每12h 给药1 次，连续7 d。第5 次给药后给予大鼠皮下注射盐酸肾上腺素( 0. 7 mg /kg) 2 次，间隔4 h，中间给予冰水刺激以复制大鼠急性血瘀证模型。末次给药30 min 内取腹主动脉血检测凝血指标和不同切变率下的全血粘度指标( WBV) 。结果与空白对照组比较，模型组大鼠1 s，5 s，30 s，200 s 切变率全血粘度普遍升高，血浆凝血酶时间( TT) 、血浆凝血酶原时间( PT) 、活化部分凝血活酶时间( APTT) 缩短，纤维蛋白原( FIB) 含量增加，差异均有统计学意义( P ＜ 0. 05) 。与模型组比较，HSYA 组、β － BA 组、联合用药组大鼠1s，5 s， 30s， 200s 切变率全血粘度降低，血浆TT、PT、APTT 延长，FIB 含量减少，差异均有统计学意义( P ＜ 0. 05) 。结论HSYA 联用β － BA 能显著改善血瘀证大鼠凝血功能和在不同切变率下的全血粘度。

关键词: <, p>, 血瘀证, 全血粘度, 凝血功能<, /p>