Abstract: Abstract: Objective To discuss the reason which susceptibility to alopecia for SPF experimental rats in our center，and to provide the basis for scientific feeding management． Method Through the observation of the characteristics of SPF experimental rats with alopecia， sterilization effect and nutrients of the growth and reproduction group rat feed were detected． Combined with the results to improve the feed formulation，then gave the treat test and observe the effect． Ｒesult Vitamins and trace elements content change greatly in high-pressure feed．Use irradiated feed and intensive therapy as vitamins，hair growth results improved significantly． Conclusion The reason for alopecia of SPF experimental SD rats was determined to decrease of vitamins in feed during pulsating vacuum steam sterilization． It's more scientific to use irradiated feed in daily feeding．

Key words: <p>SPF rats, alopecia, feed nutritional, therapy</p>

摘要： 摘要: 目的针对本中心SPF 级实验大鼠易发生的脱毛现象分析其原因，以对实验大鼠的养殖管理提供更加科学的建议。方法通过观察本单位SPF 实验大鼠脱毛的特点，对生长繁殖群常用大鼠饲料的灭菌效果和营养成分进行检测，结合检测结果改进饲料配方，进行治疗试验并观察效果。结果饲料高压灭菌后维生素和微量元素含量变化量较大，使用辐照灭菌饲料以及将维生素含量调整后大鼠脱毛改善情况最明显。结论饲料经过高压灭菌后营养中的维生素含量损失可能是造成SPF 大鼠脱毛的重要原因，在日常饲养中使用辐照饲料更加科学。

关键词: <, p>, SPF 大鼠, 脱毛, 饲料营养, 治疗实验<, /p>