Abstract: Abstract: The transporter associated with antigen processing ( TAP) is a heterodimeric protein，and the TAP1 and TAP2 subunits are encoded by closely linked genes in the MHC． TAP is essential for peptide delivery from the cytosol into the lumen of the endoplasmic reticulum ( ER ) ， where these peptides are loaded on major histocompatibility complex ( MHC) I molecules to form a complex． The lack and mutation of TAP protein may infect the presentation of antigen peptide and further harm the function of immune response．

Key words: TAP, antigen presentation, MHC class I molecule

摘要： 摘要: 抗原处理相关转运体( TAP) 属于 ABC( ATP-binding cassette) 转运体超家族的 B 亚家族，是由主要组织相容性 复合体( Major histocompatibility complex ，MHC) 上 2 个紧密连锁的基因 TAP1 和 TAP2 编码蛋白组成的异二聚体，位 于内质网和顺式高尔基膜上，功能是将抗原肽从细胞质转运进入内质网池，组装到 MHC I 类分子上构成复合体。 TAP 蛋白的缺乏和突变会影响抗原肽的提呈，最终损害免疫应答功能。

关键词: 抗原处理相关转运体, 抗原呈递, MHC I 类分子