Abstract: Abstract: Objective To investigate the differences in growing development and reproductive performance between p53 knockout mice and BALB /c mice． Method 34 p53 knockout mice with half males and half females and 34 BALB /c mice ( half male and female) were adopted in the trial，and their body weight and body length were measured from 2 to 12 weeks of age． Litter sizes at the second parity from 30 pairs of mice were checked． Result The difference in body weight between 3 － week old p53 knockout mice and BALB /c mice was not significant ( P ＞ 0. 05) ，and body weight of 6 － week old p53 knockout mice was significantly lower than that of 6 － week old BALB /c mice ( P ＜ 0. 05) ． Body length of 3 － week and 6 － week old p53 knockout mice was significantly lower than that of 3 － week and 6 － week old BALB /c mice ( P ＜ 0. 05) ． Reproductive performance of p53 knockout mice was significantly lower than that of BALB /c mice ( P ＜ 0. 05) ． Conclusion p53 gene knockout could exert significant effect on the growing development and reproductive performance of the mice．

Key words: p53 knockout mice, growing development, reproductive performance

摘要： 摘要: 目的观察p53 基因敲除小鼠与BALB/c 小鼠在生长发育和繁殖性能方面的差异。方法p53 基因敲除小 鼠和BALB/c 小鼠各34 只，雌雄各半，观察其2 周龄至12 周龄的体质量和体长，并随机选取30 笼一雌一雄所产第 2 胎仔鼠进行幼仔个数的统计。结果在生长发育方面，3 周龄时p53 基因敲除小鼠与BALB/c 小鼠体质量无明显 差异，P = 0. 846 ＞ 0. 05; 6 周龄时p53 基因敲除小鼠体质量明显低于BALB/c 小鼠，P = 0. 000 ＜ 0. 05; 体长在3 周龄 和6 周龄时p53 基因敲除小鼠体长明显低于BALB/c 小鼠，P = 0. 000 ＜ 0. 05。在繁殖性能方面，p53 基因敲除小鼠 同样明显低于BALB/c 小鼠，P = 0. 000 ＜ 0. 05。结论初步研究了p53 基因敲除对小鼠的繁殖与发育的影响，与 BALB/c 小鼠比较均有显著差异。

关键词: p53 基因敲除小鼠, 生长发育, 繁殖性能