Abstract: Abstract: Objective Establishment a novel hemisected spinal cord injury model with rats to supply model for clinical research． Method 25 SD rats were randomly divided into wedged-block hemisected group ( A group，n = 10) ，sham operation group( B group，n = 10) and control group ( C group，n = 5) ． After operation，the stability of the model was comprehensive evaluated by grading the scores of Basso-Beattie-Bresnahan ( BBB) ， swash plate test， HE staining and MRI assay． Result After operation，the mean scores of BBB in injured hind limb and maximum angle of swash plate in group A were significantly lower than group C and B( P ＜ 0. 05) ，but these parameters without different between B group and C group; 28 days after operation，HE staining and MRI assay shows a significant morphological changes in spinal cord tissue of group A; Conclusion The results suggested that the rat model established by this method with high quality of stability and reliability which suitable to evaluate the spinal cord injury research．

Key words:  wedge-shaped spinal cord hemisection, model, rats

摘要： 摘要: 目的建立一种新型大鼠脊髓半切模型，为临床脊髓空洞损伤研究提供适宜的动物模型。方法25 只SD 大鼠随机分为脊髓楔型块状半切组( A 组，n = 10) 、假手术组( B 组，n = 10) 和正常对照组( C 组，n = 5) 。术后采用 BBB 运动功能评分、斜板试验、HE 染色和核磁共振( MRI) 检测综合评价脊髓半切模型的稳定性。结果术后A 组 大鼠伤侧后肢BBB 运动功能评分及斜板维持最大角度值显著低于B 组和C 组( P ＜ 0. 05) ，而这些指标在B 组和C 组之间没有明显差异; 术后28 d HE 和MRI 检测显示脊髓损伤区( A 组) 灰质和白质发生明显的形态学改变。结论 通过该方法建立的脊髓半切模型稳定、可靠，适于脊髓空洞性损伤的研究。

关键词: 脊髓楔型半切, 动物模型, 大鼠