Abstract: Objective To study the effects of ethionine on lipid metabolism in mice,in order to provide a gist of decision-making for the time of drug administration for preventing fatty liver in mice.Methods Mice were divided to six groups.serum TG and TC or hepatic TG and TC were detected in normal group,and experimental group at the different time(6,12,24,36,48 h)after taking ethionine orally.Result Serum TG increased significantly during 6～48 h,and serum TC was increased significantly during 6～36 h after ethionine administration.Furthermore hepatic TG was increased significantly during 6～36 h,and hepatic TC was reduced significantly during 24～36 h after ethionine administration.Conclusion Ethionine-induced fatty liver in mice was stable during 6～36 h after administration.

Key words: Fatty liver, Mouse model, Ethionine, Lipid metabolism

摘要： 目的观察乙硫氨酸所致小鼠脂肪肝模型不同时间脂代谢的变化,为利用该模型研究抗脂肪肝药物及选择适宜的给药时间提供科学依据。方法小鼠分为6组,分别检测正常组血脂、肝脂及灌服乙硫氨酸后6、12、24、36、48h各组动物的血脂、肝脂变化。结果小鼠灌服乙硫氨酸后,血清TG在造型后6～48h显著升高,血清TC在造型后6～36h显著升高;肝脏TG在造型后6～36h显著升高,肝脏TC在造型后24～36h显著降低。结论乙硫氨酸诱导的小鼠脂肪肝模型在6～36h比较稳定。

关键词: 脂肪肝, 小鼠模型, 乙硫氨酸