Abstract: Objective To provide reference for laboratory animal production and management by analyzing of the recent three years test results on microbes and parasites of commonly used laboratory animals in Beijing area,which covered the conventional Beagle dogs,the conventional rabbits,the clean and over rats(strains of Wistar and SD) and mice(strains of KM and ICR).Methods The microbes and parasites of laboratory animal samples were tested according to the current national standards described in 《Laboratory animal—microbiological standards and monitoring》 and 《Laboratory animal—parasitic standards and monitoring》.Results The quality of conventional Beagle dogs was found to be improved gradually,but the exterior parasites had still been detected occasionally.The exterior parasites of conventional rabbits had been found universally.The test results on microbes and parasites of clean rats and mice were basically qualified,but there were positive samples of interior parasites.In addition,the amount of the SPF laboratory animals was very small that the needs of scientific research work were not fully met.Suggestions To improve the quality of the laboratory animals producers,our suggestions are following:Improving the managing level of the conventional animals and enhancing the preventive immunity to keep them away from the infectious and parasitic diseases.Enhancing the purification of the clean animals and improving the efficiency of the material disinfection to ensure the quality of the clean animals qualified and stable.Further improving the purification of laboratory animals and expanding the productive scale of the SPF laboratory animals to fully meet the needs of scientific research work.

Key words: Beijing Area, Laboratory Animals, Microbes, Parasites

摘要： 目的对2006年～2008年北京地区普通Beagle犬、大耳白兔和清洁以上大鼠(Wistar和SD品系)、小鼠(KM和ICR品系)微生物和寄生虫的抽检结果进行分析,为实验动物生产管理提供参考。方法按现行国标《实验动物微生物学检测方法》和《实验动物寄生虫学检测方法》,抽检动物所携带的微生物和寄生虫。结果普通Beagle犬的质量虽在逐渐提高,但体外寄生虫时有检出;普通大耳白兔体外寄生虫的携带较为普遍;清洁大鼠和小鼠的微生物检测结果基本合格,但有体内寄生虫的阳性样本;SPF级大鼠和小鼠的供应数量较少,尚不能充分满足科研工作的需要。建议有关实验动物生产单位加强普通动物的防疫工作,同时改进饲养管理水平,以有效避免传染病和寄生虫病的发生;加强清洁动物的净化及物料的消毒工作,以确保清洁动物的质量合格、稳定;进一步提高实验动物的净化水平并扩大SPF动物的生产规模,以充分满足科研工作的需要。

关键词: 北京地区, 实验动物, 微生物, 寄生虫