Abstract: Objective To investigate the cause of unusual pregnancy in rhesus macaques breeding colony.Methods Several factors relating to unusual pregnancy,such as infective pathogens(toxoplasma,Tox),environmental elements and other factors with the similar physiology and biological character in human,were analyzed.In this study,29 samples were collected from unusual pregnancy cases and Toxoplasma gondii DNA extracted from blood was examined,using normal delivery group and normal adult macaque group as controls.Results Statistical results showed that toxoplasma infective rate of the unusual pregnancy samples were 34.4%,significantly higher than those of the normal delivery group(12.5%,P<0.05) and the normal adult macaque group(5.0%,P<0.05).The unusual pregnancy rates were significantly different among macaques housed in distinct environments.Conclusion Toxoplasma infection,environment,maternal age and parity,are the factors relating to unusual pregnancy of rhesus macaques,which will be decreased according to our proposed measures.

Key words: Rhesus macaque, Unusual pregnancy, Toxoplasma gondii, Environment

摘要： 目的猕猴作为珍贵的实验动物,资源逐步匮乏,医学生物学研究所灵长类中心笼养猕猴种群自然流产、难产、早产和死胎(统称为妊娠异常)病例时有发生,带来了一定的损失。因此,逐一查找猕猴妊娠异常原因,针对性地提出预防和控制措施,对提高猕猴繁殖率保护猕猴资源具有重大现实意义,同时也为研究人的生殖机理奠定基础。方法通过参照引起人自然流产的因素,又考虑到猴自身的特性,主要从以下方面入手来分析猕猴妊娠异常原因:病原体,猴易感的弓形虫(Tox,toxoplasma),环境因素及其他因素。实验中,我们对三年来收集的29例妊娠异常雌猴样品进行病原体检测分析,并与正常分娩组和正常猴群组做对照。结果统计结果显示,妊娠异常组猕猴弓形虫感染率达34.4%,明显高于正常分娩组(12.5%)和正常猴群组(5%);不同的饲养环境中妊娠异常猕猴的数量也有显著差异。结论弓形虫感染、环境条件造成的应激反应及猕猴自身条件都与猕猴妊娠异常相关,对此,我们针对性地提出了预防和控制措施来降低妊娠异常率。

关键词: 猕猴, 妊娠异常, 弓形虫