Abstract: Objective To investigate the effect of nasal aerosol on the behavior and symptom of experimental migraine rat model.Methods Sixty SD rats were divided randomly and evenly into 6 groups: blank control group,model group,positive drug group and 3 treatment groups.The treatment groups included the model rats which were administrated with high,middle and low doses of nasal aerosol respectively;the positive drug group received gastric perfusion of Tiansu,and distilled water was given by gastric perfusion to the model group and the blank control group.Behavior and symptom changes of the rat models were observed continuously at various time intervals.Results The behavior and symptom of treatment groups were significantly better than that of model group.Conclusion The nasal aerosol improves the behavior and symptom of migraine rats greatly.

Key words: Migraine model, Nasal aerosol, Nitroglycerin, Behavior and symptom

摘要： 目的探讨鼻疗法喷剂对硝酸甘油所致偏头痛大鼠模型行为症状的影响。方法60只大鼠分为6组:空白、模型、阳性药、大、中、小剂量组,应用硝酸甘油制作实验性偏头痛大鼠模型,造模后30 min,空白、模型组灌胃生理盐水,阳性药组灌胃天舒胶囊溶液,大、中、小剂量组分别滴以不同剂量的鼻疗法喷剂,采用时间分段计数法持续观察给药后大鼠行为症状变化。结果治疗组行为症状显著好于模型组。结论鼻疗法喷雾剂对硝酸甘油所致实验性偏头痛大鼠模型行为学症状有较明显的缓解作用。

关键词: 偏头痛, 鼻疗法喷剂, 硝酸甘油, 行为症状