Abstract: Objective To observe the anesthetic effect of ketamine in combination with sumianxin II on cynomolgus monkey.Methods One hundred and fifty-four cynomolgus monkeys were anesthetized using sumianxin Ⅱ(0.1 mL/kg,im) and ketamine(0.1 mL/kg,im) for renal transplantation,and maintenance of anesthetic and analgesic effects,breathing frequency(BR),heart rate(HR),and resuscitation time after operation,were monitored.Results All the monkeys survived,and none of them died of anesthesia;the maintained anesthetic time was 50～70 mins after first administration.During operation,the BR and HR were(40～55)/mins and(60～74)/mins respectively.All the cynomolgus monkeys waked up in(25～35) mins after operation.Conclusions It is a good anesthesia method to use ketamine in combination with sumianxin Ⅱ,and the does is reduced considerably.The cynomolgus monkeys waked up soon after operation.The muscle is well relaxed,and BR and HR are kept stable during anesthesia.It is an excellent and safe method to anesthetize cynomolgus monkey that using ketmine in combination with sumianxin Ⅱ.

Key words: Ketamine, Sumianxin Ⅱ, Cynomolgus monkey, Anesthesia

摘要： 目的观察联合应用氯胺酮和速眠新Ⅱ对食蟹猴的麻醉效果。方法采用速眠新Ⅱ(0.1 mL/kg)肌内注射和氯胺酮(0.1 mL/kg)肌内注射联合麻醉方法对154例实施肾脏移植手术的食蟹猴进行麻醉,观察动物麻醉维持时间、镇痛效果、呼吸频率和心率变化及术后苏醒情况。结果154例肾移植食蟹猴无一只在手术过程中因麻醉意外死亡;首次麻醉维持时间为(50~70)min,追加麻醉维持时间为(30~35)min,术后苏醒时间为(25~35)min。麻醉期间肌肉松弛效果好,动物呼吸和心率平稳,手术过程中呼吸频率(40~55)次/min,心率(60~74)次/min。结论氯胺酮联用速眠新Ⅱ复合麻醉对食蟹猴是一种比较理想的麻醉方法,麻醉效果好,术后苏醒快且动物麻醉安全性高。

关键词: 氯胺酮, 速眠新Ⅱ, 食蟹猴