Abstract: Objective To study the mechanism of anti-oxidative activity and the anti-oxidative effect of gynostemma and hawthorn extracts on aging mouse model.Methods The aging mice were induced by ip injection of D-galactose for 8 weeks and were given the different doses of gynostemma and hawthorn extracts.Eight weeks later,malondialdehyde(MDA),superoxide dismutase(SOD) and glutathione peroxidase(GSH-P_X) in sera and livers were detected.Results Gynostemma and hawthorn extracts not only significantly reduced the contents of MDA but also increased the activity of GSH-P_X in sera and livers of the aging mice.Conclusion Gynostemma and hawthorn extracts have good anti-oxidative effect.

Key words: D-galactose, Aging, Ginsenosides, Flavonoids

摘要： 目的研究绞股蓝、山楂提取物的协同抗氧化活性,探讨抗衰老作用机制。方法小鼠颈背部皮下注射D-半乳糖建立衰老模型,灌胃给予不同剂量的绞股蓝、山楂提取物,检测小鼠血液和肝脏组织中的丙二醛(MDA)含量以及超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的活力。结果绞股蓝、山楂提取物协同能显著降低衰老模型小鼠血清和肝组织MDA水平,同时可提高GSH-PX活力水平。结论绞股蓝、山楂提取物协同具有显著的抗氧化作用,对衰老的自由基学说提供有力的支持。

关键词: D-半乳糖, 衰老, 绞股蓝皂甙