Abstract: The experiment proved that elevation of blood pressure and cardio acceleration from nicotine can be blocked by the two drugs on the rat. Elevation of blood pressure from nicotine can be blocked by large dose of chlorisondamine (10 mg/kg) . Mecamylamine can only block cardio acceleration from nicotine on the rat, but long-term uses of mecamylamine do not block the effects of nicotine to cardiovascular system. The block function of effects from nicotine to cardiovascular system of chlorisondamine better than that of mecamylamine. The block function of large dose of chlorisondamine to ganglions can change the heart rate and blood pressure, and the heart rate and blood pressure changes controlled by block level of different dose of chlorisondamine and mecamylamine.

Key words: Nicotine, Cardiovascular, Chlorisondamine, Mecamylamine

摘要： 目的本试验通过给大鼠注射不同剂量的氯异吲哚铵和梅坎米胺,来观察其对心血管功能的影响。实验表明大剂量的氯异吲哚铵对神经节的阻断作用能改变心率和血压,而心率和血压的改变受氯异吲哚铵和梅坎米胺不同剂量对神经节的阻断程度的控制,在注射氯异吲哚铵和梅坎米胺30min～3d的时间里能够有效的对抗烟碱作用引起的心率和血压的增加。

关键词: 烟碱, 心血管, 氯异吲哚铵, 四甲双环庚戊安