Abstract: Objective To measure the organ weight and organ coefficient of B_6;129-Gt(ROSA)26Sor mice.Methods 5～6 weeks male and 6～7 weeks female mice(15 in each group) were used in this experiment.The weight of various organs was measured using a Sartorius BP121S electronic balance.Results Between female and male mice,the body weight,the heart,kidney weight showed very significant difference(P<0.01);the liver,adrenal weight showed significant difference(P<0.05);the coefficient of liver,lung,kidney,brain,and adrenal showed very significant difference(P<0.01),but no significant difference was seen in other organ coefficient.Conclusion The weight of some main organs and organ coefficient in different gender ROSA mice are significantly different;the above data could be useful in the biomedical researches.

Key words: Genetically engineered mice, Organ weight, Organ coefficient

摘要： 目的测定基因工程B6;129-Gt(ROSA)26Sor小鼠主要脏器重量和脏器系数。方法实验选用5～6周雄性、6～7周雌性小鼠各15只,用Sartorius电子天平分别测定体重和10个主要脏器重量,计算脏器系数,并对雌雄脏器重量和脏器系数之间进行比较。结果雌雄小鼠脏器重量间比较,雄性鼠体重明显大于雌性的体重(P<0.01)、心、肾的重量间差异极显著(P<0.01);肝脏、肾上腺间比较差异显著(P<0.05)。雌雄间脏器系数比较,肝脏、肺脏、脑、肾、肾上腺间差异极显著(P<0.01),心、脾、胰脏间差异不显著(P>0.05)。结论转基因ROSA小鼠不同性别对脏器重量及脏器系数有一定的影响,同时该数据为其它相关研究提供参考。

关键词: 基因工程小鼠, 脏器重量, 脏器系数