Abstract: Objective To observe and compare effects of three different illumination durations on growth,development and reproduction of BALB/c nude mice.Methods Newborn BALB/c nude mice were fed under three different illumination durations,and their growth and development were observed.Mating and delivery intervals,delivery frequency,and number born were observed in female BALB/c nude mice,and rate of offspring survival was recorded.Some blood biochemical indexes were determined by LX20 semi-automatic analyzer.Results The differences in growth and development of newborn BALB/c nude mice were not significant among three different illumination durations(P>0.05).The average rate of offspring survival in the group of middle illumination duration was significantly higher than that in the group of long illumination duration(P<0.05).The differences in ALT,TB and SUA between the group of middle illumination duration and the group of long illumination duration were significant statistically(P<0.05). Conclusion The middle and short illumination durations are more suitable to growth,development and reproduction of BALB/c nude mice than long illumination duration.

Key words: Illumination duration, BALB/c nude mice, Blood biochemical indexes, Growth and development

摘要： 目的比较不同光照时间对BALB/c裸小鼠的影响。方法观察裸小鼠出生后在不同光照时间里的生长情况;记录雌鼠的交配分娩间隔、生产胎数、产仔数及育成率;测定血液生化指标。结果各组裸小鼠的生长差异不显著(P>0.05);中光照组的平均育成率和离乳裸鼠育成率与长光照组比较差异显著(P<0.05);中光照组的ALT、TB、SUA与长光照组比较差异显著(P<0.05)。结论中光照和短光照适宜BALB/c裸小鼠的生长发育和繁殖。

关键词: 光照, BALB/c裸小鼠, 血液生化指标, 生长发育