Abstract: ObjectiveTo study the effects of testosterone of physiological dose on glucose and lipids metabolism of male aging rats with diabetes.Methods The male aging SD rats were injected with alloxan through tail vein,and after 72 hours the rats with increase of fasting blood-glucose and abnormality of glucose tolerance test for 2 hours were selected and randomly divided into the control group and the treatment group.Testosterone propionate was intramuscularly administered into the rats of the treatment group at a dose of 2 mg/kg,two times every week.After treating for 35 days,fasting blood-glucose,blood-lipoids,and glucose tolerance were determined.Results After treating for 35 days,fasting blood-glucose,and blood-glucose of glucose tolerance test for 30,60,and 120 minutes in the treatment group were significantly lower than those in the control group.The triglyceride level in the treatment group was significantly lower than that in the control group,and the differences in total cholesterol,low density lipoprotein,and high density lipoprotein levels between the two groups were not significant.Conclusion Testosterone is able to produce a decrease in the fasting blood-glucose level and improve the glucose tolerance in the male aging rats with diabetes.

Key words: Testosterone, Aging SD rat, Diabetes

摘要： 目的探讨生理剂量的睾酮能否改善老年雄性糖尿病大鼠的糖代谢。方法用6~7月龄雄性SD大鼠给小剂量的四氧嘧啶,72 h后筛选空腹血糖高和2 h糖耐量异常的动物随机分为对照组和给药组,给药组每周两次给丙酸睾酮2 mg/kg,35 d后测空腹血糖、血脂和糖耐量。结果给药组空腹血糖显著低于对照组;糖耐量试验在30、60和120 min血糖均比对照低;给药组甘油三脂比对照组明显降低,总胆固醇、低密度脂蛋白和高密度脂蛋白两组没有区别。结论睾酮能降低老年雄性糖尿病大鼠的空腹血糖和改善糖耐量。

关键词: 睾酮, 老年, 糖尿病