Abstract: Objective To measure and analyze the main organ weight and coefficients of SD rats in a barrier system and individually ventilated cages.Methods Total 60 SD rats were used in this study,30 in each group.The rats were raised in a barrier system and IVC for 120 days.The main organ weight and coefficient for heart,liver,spleen,lung,kidney;adrenal,brian testis uterus,ovary were then measured using an electronic scales.Result between female SD rats,spleen weight showed significant difference(P<0.01),all organ coefficients were no significant differences(P<0.05);Between male SD rats,all organ weight were no significant difference(P<0.05),kidney coefficient showed significant differences(P<0.05);between female and male,in a barrier systems and IVC,all organ weight showed very significant differences(P<0.01),between female and male in IVC,no differences were found in the liver and kidney coefficients(P<0.05);between female and male in close system,the organ coefficient of the heart,spleen,lung,adrenal and brain showed significant the difference(P<0.05).Conclusion The organ weight and coefficient of SD rats in a barrier system and IVC were not different significantly.

Key words: Barrier system, Individually ventilated cage(IVC), Organ weight, Coefficient of organ

摘要： 目的测定并比较分析屏障环境和IVC饲养条件下SD大鼠的主要脏器重量及脏器系数的差异。方法用电子天平分别测定了30只在屏障环境中和IVC饲养条件下SD大鼠的心、肝、脾、肺、肾、肾上腺、子宫、睾丸和卵巢的重量及脏器系数。结果雄鼠之间比较,脾脏重量差异显著,其它各脏器系数间无显著性差异;雌鼠之间比较,各脏器重量间无显著性差异,肾脏系数差异显著(P<0.05);两种条件下,雄雌鼠之间脏器重量比较差异非常显著(P<0.01),IVC雄雌之间脏器系数比较,肝、肾间无显著性差异,其它差异非常显著;屏障条件下,雄雌之间脏器系数比较,心、脾、肺、肾上腺、脑差异显著(P<0.05),肾无差异。结论屏障环境和IVC条件下饲养的SD大鼠脏器重量及脏器系数间差异较小。

关键词: 屏障环境, IVC, 脏器重量, 脏器系数