Abstract: Objective To delve into the relationship of blood-lipid to serum bilirubin in ApoE gene-knockout mice.Methods Male ApoE gene-knockout mice of twelve-month-old were selected in this study,and male C57BL/6J mice of twelve-month-old were used as controls.The levels of TG,TC,LDL-C,ApoB,T-BIL,and D-BIL in serum were determined in these mice.Results The serum levels of TG TC,LDL-C,ApoB in ApoE gene-knockout mice were significantly higher than those in C57BL/6J mice(P<0.01),and the serum level of D-BIL in ApoE gene-knockout mice was significantly lower than that in C57BL/6J mice(P<0.01).Conclusion Blood-lipid of the mice with atherosclerosis was correlated with serum bilirubin.

Key words: Atherosclerosis, Serum lipid, Bilirubin, Mice

摘要： 目的探讨动脉粥样硬化小鼠血脂与血清胆红素之间的关系。方法选取12月龄雄性动脉粥样硬化小鼠及同龄同性别正常对照C57BL/6J小鼠,分别测定血清甘油三酯、胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、载脂蛋白B水平、血清总胆红素、直接胆红素。结果动脉粥样硬化小鼠胆固醇、低密度脂蛋白、高密度脂蛋白、载脂蛋白B水平与同龄同性别的C57BL/6J小鼠相比极显著升高(P<0.01);动脉粥样硬化小鼠直接胆红素水平与C57BL/6J小鼠相比极显著降低(P<0.01)。结论动脉粥样硬化小鼠血脂与血清胆红素相关。

关键词: 动脉粥样硬化, 血脂, 胆红素