Abstract: Objective This paper studies applicability of the IRM_2 mice spontaneous tumor to different series host mice,so that it can provide widely assay basis for application of the tumor.We have studied repellency of the IRM_2 mice spontaneous lymphoma,the mouse sarcoma S_(180) and the cervical cancer U_(14) to different hosts,respectively. Methods\ Useing S_(180) and U_(14) as control groups, we transplanted the IRM_2 mice lymphoma,S_(180) and U_(14) to ICR, IRM_2 and hairless (HL),KM mice,and weighting tumors after growing 10 days,respectively. Results\ The S_(180) and U_(14) can be transplanted successfully, whereas the IRM_2 mice lymphoma can't grow in ICR,HL and KM mice using the implanted means of different cell concentration. Conclusion\ S_(180) and U_(14) are applicability to different hosts,while the IRM_2 mice spontaneous lymphoma is just reverse.

Key words: IRM_2 mice, spontaneous lymphoma, S_(180), U_(14), transplant

摘要： 目的研究IRM_2小鼠自发淋巴瘤是否适应其它品系的小鼠,为更好地使用该小鼠自发肿瘤提供实验依据。我们研究了IRM_2小鼠自发淋巴瘤、肉瘤S180、宫颈癌U14对多种宿主的排斥性。方法采用S180、U14肿瘤为对照,将IRM_2小鼠淋巴瘤、S180、U14用多种方法接种于ICR、IRM_2、HL和KM等小鼠身上,于10~12d后取出肿瘤称重。结果多种方法接种S180、U14于几种小鼠身上都能使肿瘤生长;而多种比例浓度的方法接种IRM_2小鼠自发淋巴瘤于ICR、KM、HL身上肿瘤都不生长。结论S180、U14对宿主无排斥性,而IRM_2小鼠白发淋巴瘤对宿主有排斥性。

关键词: IRM-2小鼠自发淋巴瘤