Determination of Hematological and Biochemical Parameters of Mice Lacking Smad3 ——70 Days Old of Mice Lacking Smad3

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Determination of Hematological and Biochemical Parameters of Mice Lacking Smad3 ——70 Days Old of Mice Lacking Smad3

ZHAN Da-wei, WANG Dong-ping, LUAN Rong-hui, SUN Yan-song, LI Ji-qing, LI Wen-long, SHI Yan-sheng, LI Gui-jun, ZHANG Ai-lan

(Laboratory Animal Center, Academy of Medical Sciences, Beijing 100071

Received:2002-03-25 Revised:2002-03-25 Online:2002-03-25 Published:2002-03-25

Smad3基因剔除小鼠的血液生理生化指标检测——70日龄Smad3小鼠

战大伟,王冬平,栾蓉晖,孙岩松,李吉庆,李文龙,时彦胜,李桂军,李爱兰

军事医学科学院实验动物中心,军事医学科学院实验动物中心,军事医学科学院实验动物中心,军事医学科学院实验动物中心,军事医学科学院实验动物中心,军事医学科学院实验动物中心,军事医学科学院实验动物中心,军事医学科学院实验动物中心,军事医学科学院实验动物中心北京100071

Abstract

Abstract: Hematological and blood biochemical index of Smad3 mice of the 70d old were determinated. The results showed: there were a few significant differences in mice between sexes(male and female mice). The parameters of the WBC and hemoblast of homozygous mutants were higher than those of heterozygous mutants wild-types. The parameters of CER、CK、UA、GOT、TP、ALP、LDH-L、MG、CA were significant among three types through statistics. The parameters of CK、UA、TG、ALP、LDH-L of homozygous mutants were higher than those of wild-types, but the parameters of GLU、P、MG、CA were in reverse.

Key words: Mice lacking Smad3, Hematological parameters, Biochemical parameters

摘要： 对成年 70日龄的Smad3基因剔除小鼠血液生理生化指标进行检测 ,结果只有少数指标雌雄之间差异显著 ,纯合型 (- - )小鼠的白细胞 (WBC)和血小板高于杂合型 (+ - )和野生型 (+ +)小鼠。各项生化指标三种表型之间方差分析CER、CK、UA、GOT、TP、ALP、LDH L、MG、CA差异显著 ;纯合型 (- - )的CK、UA、TG、ALP、LDH L指标高于野生型的小鼠 ;GLU、P、MG、CA指标低。

关键词: Smad3基因剔除小鼠, 血液学, 血液生化

ZHAN Da-wei, WANG Dong-ping, LUAN Rong-hui, SUN Yan-song, LI Ji-qing, LI Wen-long, SHI Yan-sheng, LI Gui-jun, ZHANG Ai-lan. Determination of Hematological and Biochemical Parameters of Mice Lacking Smad3 ——70 Days Old of Mice Lacking Smad3[J]. laboratory animal science.

战大伟,王冬平,栾蓉晖,孙岩松,李吉庆,李文龙,时彦胜,李桂军,李爱兰. Smad3基因剔除小鼠的血液生理生化指标检测——70日龄Smad3小鼠[J]. 实验动物科学.

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