Abstract: In order to investigate the availability of animal models of liver fibrosis,carbon tetrachloride(CCl 4)and human serum albumin(HSA) induced rats liver fibrosis were developed and survival rates,serum concentration of ALT,AST,LDH,hepatic collagen contents and pathological examination were served as observing parameters.Results showed that these indicators in two models group were significantly different from those of normal group.They could reflect the formation of liver fibrosis and could be selected as observing parameters for treatments of experimental liver fibrosis.

Key words: Human serum albumin, Carbon tetrachloride, Liver fibrosis, Animal model

摘要： 本文以大鼠为实验动物 ,对四氯化碳、人血白蛋白所致的肝纤维化动物模型 ,与正常大鼠从存活率 ,血清ALT、AST、LDH、肝组织胶原蛋白含量 ,肝脏病理学表现等几个方面进行了比较 ,各项测试指标与正常大鼠比较差异极为显著 ,均能反映出肝纤维化的形成 ,各项测试指标可作为实验性肝纤维化治疗研究的参考指标

关键词: 人血白蛋白, 四氯化碳, 肝纤维化, 动物模型