Abstract: Objective To explore the effects of three kinds of drinking water on blood indexes in NIHmice. Method 54 NIH mice were randomly divided into three groups, drinking autoclaved water,autoclaved acidified water and sterile water bag water ( membrane filtered water) , respectively. On the30th, 60th, and 90th days of the experiment, blood was taken for blood routine and biochemical tests,and liver tissue was taken for histopathological examination to explore the effects of three kinds of drinkingwater on the health status of mice. Result The albumin ( ALB) in the 60 day water bag group wassignificantly higher than that in the autoclaved water group ( P < 0. 05) , the total protein ( TP ) in theautoclaved acidified water group was significantly higher than that in the autoclaved water group ( P <0. 01) , and there was no significant difference between the other groups ( P > 0. 05 ) . The liverhistopathological result showed that no pathological changes were found in the liver tissues of mice in eachgroup, and they were normal liver tissues. Conclusion Three kinds of drinking water have no significantimpact on the health status of NIH mice.

Key words: three kinds of drinking water, NIH mice, blood indicators

摘要： 目的 探讨三种饮用水对 NIH 小鼠血液指标的影响。 方法 将 54 只 NIH 小鼠随机分为 3 组,分别饮用高压灭菌水、高压酸化水和无菌水袋水(膜过滤水) ,在实验 30、60 和 90 d 分别取血进行血常规和血生化检测,并取肝组织进行组织病理学检查,探讨三种饮用水对小鼠健康状态的影响。 结果 60 d 水袋水组白蛋白( ALB) 显著高于高压灭菌水组(P<0. 05) ,酸化水组总蛋白( TP)极显著高于高压灭菌水组( P< 0. 01) ,其他生化和血常规指标组间无统计学意义(P>0. 05) ,肝组织病理学结果显示各组小鼠肝组织未发现病变,为正常肝组织。 结论 三种饮用水对NIH 小鼠健康状态无明显影响

关键词: 三种饮用水, NIH 小鼠, 血液指标