关于肿瘤移植模型病理学方面的探讨

实验动物科学

关于肿瘤移植模型病理学方面的探讨

叶明霞,孔利佳,周顺长,许迪,任大宏

同济医学院实验动物学部,同济医学院实验动物学部,同济医学院实验动物学部,同济医学院实验动物学部,同济医学院病理教研室武汉430030 ,武汉430030 ,武汉430030 ,武汉430030 ,武汉430030

收稿日期:2002-09-25 修回日期:2002-09-25 出版日期:2002-09-25 发布日期:2002-09-25

Study on Establishing The Replanting Models of Strain S_(180)and EAC

YE Ming xia, KONG Li jia, ZHOU Shun chang, XU Di, REN Da hong

(Faculty of Laboratory Animal, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, 430030

Received:2002-09-25 Revised:2002-09-25 Online:2002-09-25 Published:2002-09-25

摘要/Abstract

摘要： 应用小鼠S1 80 肉瘤 ,小鼠EAC腹水瘤实体型两种瘤株 ,进行BALB c小鼠移植瘤模型的研究。试验设S1 80 对照组 ,S1 80 给药组 ,EAC对照组 ,EAC给药组 ,比较给药 10d后实体瘤大小及其病理学变化特征。病理学观察对照组和给药组间、瘤体切面积和瘤细胞坏死率差异均有极显著性 ,两对照组的小鼠肝脏内均发现有瘤细胞转移。由此说明病理学观察具有重要的参考价值

关键词: S180肉瘤, EAC腹水瘤, 肿瘤移植模型

Abstract: To establish the replantable models of tumon cell line S 180 and EAC using BALB/c mice respectively. The mices were randomly divided into 2 groups, with one group given therapeutic drug and the other as a control. After 10 days, the tumour weights and pathological changes were compared. There is very apparent difference of pathological changes between two groups. The tumour cells were found in the mices liver of the control groups. This proves that pathological evaluation shown a significant reference value.

Key words: Strain S 180, Strain EAC, Replanting model mice

叶明霞,孔利佳,周顺长,许迪,任大宏. 关于肿瘤移植模型病理学方面的探讨[J]. 实验动物科学.

YE Ming xia, KONG Li jia, ZHOU Shun chang, XU Di, REN Da hong. Study on Establishing The Replanting Models of Strain S_(180)and EAC[J]. laboratory animal science.