关键词: 特应性皮炎, 小鼠, 研究进展

Abstract: Atopic dermatitis ( AD) is a common chronic inflammatory skin disease. the incidence in children is almost to 20%, but now there is no cure for the disease,which seriously affects the healthy growth of infants and the quality of China’ s population. Therefore, it is important to elucidate the cause of AD to further guide the clinical treatment strategies and the development of drug targets. Disease models are the basis of research. Animal disease models can visually present the occurrence and development of AD, which is helpful to study the development law of AD. Because mice are highly homologous to human genome and highly fecund, they are often used as model animals for disease research. In this paper, we summarized the research on AD from CNKI and PubMed databases in recent years, model characteristics and molding methods of these AD mouse models to facilitate AD research.

Key words: atopic dermatitis (AD) , mice, research progress