实验动物科学 ›› 2018, Vol. 35 ›› Issue (04): 61-.
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摘要： 目的 探讨成年小鼠大脑神经细胞特异性ADAM10基因缺失后对小鼠行为的影响。方法 通过Y迷宫、高架十字迷宫以及旷场实验，了解ADAM10 基因敲除后，对小鼠的自主活动能力、探究学习能力的影响。结果 行为学实验结果显示ADAM10基因敲除小鼠的自主活动能力较对照组小鼠有所下降，其在新环境中探索的次数、时间和路程较对照组明显减少。说明了脑内神经细胞ADAM10 基因的缺失对成年小鼠的自主活动能力和探究学习能力都产生了一定的影响。
关键词: ADAM10, Y迷宫, 高架十字迷宫, 动物行为
Abstract: Objective To investigate the effect of deletion of specific ADAM10 gene in brain cells of adult mice on behavior in mice. Method Y maze, elevated plus maze and open field test were used to understand the effect of ADAM10 gene knockout on locomotor activity and inquiry learning ability in mice. Result Behavioral experiments showed that ADAM10 gene knockout mice had decreased autonomic activity compared with the control group, the frequency, time and distance were significantly lower than the control group in the new environment. It indicated that the deletion of ADAM10 gene had certain influence on the autonomic activity and inquiry learning ability of adult mice.
Key words: ADAM10, Y maze, Elevated plus maze, animal behavior
黄忠兴， 何宏星， 王亚新， 邢作超， 周常文， 林炤华. 成年小鼠大脑神经细胞特异性ADAM10基因敲除的认知功能研究[J]. 实验动物科学, 2018, 35(04): 61-.
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