实验动物科学 ›› 2017, Vol. 34 ›› Issue (03): 34-37.

• 研究 论著 • 上一篇    下一篇

某天然山泉水对高脂大鼠血脂及血流变学的影响

  

  1. ( 北京大学医学部实验动物科学部,北京 100191)
  • 出版日期:2017-06-30 发布日期:2017-09-07

Effect of Some Natural Mountain Spring on Blood Lipid and Blood Rheology in Rat Models with Hyperlipidemia

  • Online:2017-06-30 Published:2017-09-07

摘要: 摘要: 目的 观察某天然山泉水对实验性高脂大鼠血脂及血流变学的影响。方法 24 只 SD 大鼠根据血清总胆固醇( TC) 水平随机分为某天然山泉水组和模型对照组。采用高脂饲料喂养建立高血脂大鼠模型,在给予高脂饲料的同时,某天然山泉水组自由饮用某天然山泉水,模型对照组自由饮用自来水,连续饮用 60 d 后,采血测定血脂和血流变学指标。结果 与模型对照组比较,某天然山泉水组甘油三酯( TG) 显著降低( P < 0. 05) ,低密度脂蛋白胆固醇( LDL-C) 极显著降低( P < 0. 01) ; 与模型对照组相比,某天然山泉水组切变率为 200s - 、100s - 和 50s - 时,全血黏度均极显著降低( P < 0. 01) ,切变率为 10s - 时,全血黏度显著降低( P < 0. 05) ; 红细胞压积显著降低( P < 0. 05) 。结论 某天然山泉水具有降低实验性高脂大鼠甘油三酯和低密度脂蛋白胆固醇的作用,也具有改善血流变学的作用。

关键词: <, p>, 某天然山泉水, 大鼠, 血脂, 血流变学<, /p>

Abstract: Abstract: Objective To observe the effect of some natural mountain spring on blood lipid and blood rheology in rat models with hyperlipidemia. Method Twenty-four male rats were randomly divided into mountain spring group ( drink some natural mountain spring) and control group ( drink tap water) according to the level of TC. The hyperlipidemia rat model was established by feeding with high-fat diet. The serum in the two groups was taken for blood lipid and blood rheology analysis after sixty days. Result Compared with those of control group,the levels of TG and LDL in mountain spring group were significantly decreased ( P < 0. 05,P < 0. 01) ; Blood rheology indexes in mountain spring group were improved significantly( P < 0. 05) ,these indicators including: whole blood viscosity, hematocrit,and so on. Conclusion The result show that some natural mountain spring could significantly decreased the level of TG,and LDL-C in the rats with hyperlipidemia. It can also significantly improve the mountain spring group rats’blood rheology index.

Key words: <p>some natural mountain spring, rat, blood lipid, blood rheology</p>

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